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Six-year results of a prospective study of metal ion levels in young patients
with metal-on-metal hip resurfacings 2009
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J. Daniel, FRCS, MS(Orth), Director of Research1; H. Ziaee, BSc(Hons),
Biomedical Scientist1; C. Pradhan, FRCS, MCh(Orth), Staff Orthopaedic Surgeon1;
and D. J. W. McMinn, FRCS, Consultant Orthopaedic Surgeon1
1 The McMinn Centre, 25 Highfield Road, Birmingham B15 3DP, UK.
We describe the findings at six years in an ongoing prospective
clinicoradiological and metal ion study in a cohort of 26 consecutive male
patients with unilateral Birmingham Hip Resurfacing arthroplasties with one of
two femoral head sizes (50 mm and 54 mm). Their mean age was 52.9 years (29 to
67). We have previously shown an early increase in the 24-hour urinary excretion
of metal ions, reaching a peak at six months (cobalt) and one year (chromium)
after operation. Subsequently there is a decreasing trend in excretion of both
cobalt and chromium. The levels of cobalt and chromium in whole blood also show
a significant increase at one year, followed by a decreasing trend until the
sixth year.
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