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Small donations are
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Surface Hippy.
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Cortisone and Cognitive Function Study
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Full Study http://jcem.endojournals.org/cgi/content/full/83/10/3487
In conclusion, this small prospective study in healthy older subjects
indicates that there may be an association between adrenal steroid
hormones and cognitive function. Free cortisol appeared to be associated
with cognitive impairment, and cortisol after dexamethasone
treatment increased the risk of cognitive decline. DHEAS was
inversely, but not significantly, associated with cognitive impairment
and decline. However, these results are preliminary, and larger
follow-up studies of longer duration are needed to verify these findings.
It remains unclear whether the observed cognitive impairment and
decline are the direct result of the altered levels of the peripheral
steroids or vice versa, or if another factor influences both
adrenal steroid biosynthesis and the processes leading to reduced
cognitive function.
Received September 30, 1997.
Revised June 12, 1998.
Accepted June 19, 1998.
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